Make sure you have downloaded and installed the latest version of BioExplorer (1.3 or above) from http://www.cyberevolution.com/.

Also make sure that when you first run BioExplorer, Inner Tube and Particle Editor you allow these programs to connect to the Internet (which allows them to connect to eachother via local internet protocols) by clicking "Unblock", "Always Allow" or "Permit Always" if a security alert appears from Windows, Norton, or another firewall (see detailed instructions). If you already clicked "block" or "don't allow" reinstall BioExplorer or change your blocking settings.