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Neurofeedback Research

Chronic Fatigue

Research Papers

Abnormal QEEG'S in Chronic Fatigue Syndrome Patients
by Crago R, Ph.D.

Approximately 20 patients with a medical diagnosis of chronic fatigue syndrome were evaluated using QEEG with comparison to Thatcher's reference data base. The majority of the patient's demonstrated dominent patterns of diffuse alpha with frontal intrusion and often slowed alpha. Some demonstrated dominent theta patterns.

Treatment of Chronic Fatigue Syndrome with Neurofeedback and Self-Hypnosis: A Case Report
by Hammond CD, Ph.D.

Research suggests that there may be two clusters of chronic fatigue patients: A group with relatively rapid onset and no psychiatric symptom history, and a group with a gradual onset and a significant history of depression and other psychiatric disturbance. It has been suggested that the former may represent patients most likely affected by a virus. This paper describes the treatment of a young woman with more rapid onset CFS without a psychiatric history.

A Trial of 18 Hz AVS on Attention and Concentration in Chronic Fatigue Syndrome
by Trudeau DL, M.D.

The effect of AVS on symptoms of decreased attention and concentration was studied in an uncontrolled open clinical trial in members of a CFS support group. Volunteer subjects completed written informed consent and received 60 daily sessions of AVS at a target frequency of 18Hz. Pre and post intervention QEEG's, Beck depression scale, Magill pain questionnaire, T.O.V.A., DSM-IV ADHD symptom checklist were done. None of the subjects had Wender Utah criteria for childhood ADHD.

10 Hz Elevations as the Core of Eyes Open Alpha in ADD, Chronic Fatigue, Depression
by Brown VW, Ph.D.

This presentation examines the phenomenology of the eyes open alpha demonstrated in a variety of conditions. Case review of 10 clients with mixed clinical presentation will be used to demonstrate that the core constituent of eyes open alpha elevations consists in prominent elevations at 10 Hz regardless of client presenting symptomatology.

EEG Patterns and Chronic Fatigue Syndrome
by Billiot KM M.A., Budzynski TH Ph.D., Andrasik F Ph.D.

This study examined the relationship between EEG recordings of 28 females with Chronic Fatigue Syndrome (CFS) and age matched controls of the same gender. CFS subjects' EEG recordings were also compared to their responses on the Profile of Fatigue Related Symptoms, and two questionnaires developed specifically for this study.

EEG Biofeedback as a Treatment for Chronic Fatigue Syndrome: A Controlled Case Report [abs.]
by James LC and Folen RA

EEG neurofeedback has been identified as a potential diagnostic and treatment protocol with chronic fatigue syndrome (CFS) symptoms. In the present case study, the authors applied an EEG neurofeedback biofeedback paradigm as a treatment modality with a CFS patient. Baseline data were acquired using the Wechsler Adult Intelligence Scale-Revised and qualitative and subjective ratings of cognitive improvement. Test results and clinical findings revealed improvements in the patient's cognitive abilities, functional skill level, and quality of life. The patient showed significant differences in pre- and posttest levels on the Wechsler scale.


Research Papers

Treatment of Fibromyalgia Incorporating EEG-Driven Stimulation: A Clinical Outcomes Study [abs.]
by Mueller HH, Donaldson CC, Nelson DV, Layman M

Thirty patients from a private clinical practice who met the 1990 American College of Rheumatology criteria for fibromyalgia syndrome (FS) were followed prospectively through a brainwave-based intervention known as electroencephalograph (EEG)-driven stimulation or EDS. Patients were initially treated with EDS until they reported noticeable improvements in mental clarity, mood, and sleep. Self-reported pain, then, having changed from vaguely diffuse to more specifically localized, was treated with very modest amounts of physically oriented therapies. Pre- to posttreatment and extended follow-up comparisons of psychological and physical functioning indices, specific FS symptom ratings, and EEG activity revealed statistically significant improvements.

Neurofeedback Improves Symptoms Of Fibromyalgia In A Randomized, Controlled Study
by Fisher A PHD

In a recently published article in the journal, Applied Psychophysiology and Biofeedback, researchers report that neurofeedback, a form of biofeedback, significantly improves symptoms of fibromyalgia syndrome (FMS). The authors devised a well thought out study that included a total of 36 patients who experienced FMS. Patient were randomly assigned to 1 of 2 groups: 18 in a neurofeedback group and 18 in an Escitalopram (i.e., Lexipro) group.

Neurofeedback Intervention in Fibromyalgia Syndrome; a Randomized, Controlled, Rater Blind Clinical Trial [abs.]
by Kayran S, Dursun E, Dursun N, Ermutlu N, Karamürsel S

We designed a randomized, rater blind study to assess the efficacy of EEG Biofeedback (Neurofeedback-NFB) in patients with fibromyalgia syndrome (FMS). Eighteen patients received twenty sessions of NFB-sensory motor rhythm (SMR) treatment (NFB group) during 4 weeks, and eighteen patients were given 10 mg per day escitalopram treatment (control group) for 8 weeks.

Lyme Disease

Research Papers

EEG Biofeedback in the Treatment of Lyme Disease: A Case Study
by Packard RC M.D. and Ham LP M.A.

EEG biofeedback (EBF) was evaluated in a 44-year old male with advanced Lyme disease and associated cognitive dysfunction. Reatment consisted of 40 sessions of EBF designed to suppress theta and enhance beta. Following treatment, the patient reported a 50% improvement overall in cognitive functioning. A modest improvement in theta, the theta/ beta ratio, and the P3 evoked potential were also observed. Results indicate a possible role for EBF in advanced stage Lyme disease.

Neurofeedback and Lyme's Disease: A Clinical Application of the Five Phase Model of CNS Functional Transformation and Integration
by Brown VW Ph.D.

This article presents a Five Phase Model of CNS Functional Transformation which has been developed through my work with the multiple modalities of neurofeedback treatment across a wide range of disorders. The rationale of this approach is described as well as its application to working with a particular individual suffering from Lyme's disease. In addition some ideas will be presented regarding how the overall framework of the five phases can be used to triage and treat a range of disorders including ADD, anxiety, depression, substance abuse, PTSD, and peak performance.

Recent Research

Mind over chatter: Plastic up-regulation of the fMRI salience network directly after EEG neurofeedback.
Ros T, Théberge J, Frewen PA, Kluetsch R, Densmore M, Calhoun VD, and Lanius RA
NeuroImage, 65, 2013, pp 324-35

Improving Visual Perception through Neurofeedback.
Scharnowski F, Hutton C, Josephs O, Weiskopf N, and Rees G
Journal of Neuroscience, 32, 2012, pp 17830-41

The effectiveness of neurofeedback training on EEG coherence and neuropsychological functions in children with reading disability.
Nazari MA, Mosanezhad E, Hashemi T, and Jahan A
Clinical EEG and Neuroscience, 43, 2012, pp 315-22

Self-regulation of brain oscillations as a treatment for aberrant brain connections in children with autism.
Pineda JA, Juavinett A, and Datko M
Medical Hypotheses, 79, 2012, pp 790-8

Evidence-based information on the clinical use of neurofeedback for ADHD.
Moriyama TS, Polanczyk G, Caye A, Banaschewski T, Brandeis D, and Rohde LA
Neurotherapeutics, 9, 2012, pp 588-98

Current status of neurofeedback for attention-deficit/hyperactivity disorder.
Lofthouse N, Arnold LE, and Hurt E
Current Psychiatry Reports, 14, 2012, pp 536-42

Individual alpha neurofeedback training effect on short term memory.
Nan W, Rodrigues JP, Ma J, Qu X, Wan F, Mak PI, Mak PU, Vai MI, and Rosa A
International Journal of Psychophysiology, 86, 2012, pp 83-7

Neurotherapy of traumatic brain injury/posttraumatic stress symptoms in OEF/OIF veterans.
Nelson DV, and Esty ML
Journal of Neuropsychiatry and Clinical Neurosciences, 24, 2012, pp 237-40

Schizophrenia and the efficacy of qEEG-guided neurofeedback treatment: a clinical case series.
Surmeli T, Ertem A, Eralp E, and Kos IH
Clinical EEG and Neuroscience, 43, 2012, pp 133-44

Which attention-deficit/hyperactivity disorder children will be improved through neurofeedback therapy?
Ahmadlou M, Rostami R, and Sadeghi V
Neuroscience Letters, 516, 2012, pp 156-60

Neurofeedback in children with ADHD: validation and challenges.
Gevensleben H, Rothenberger A, Moll GH, and Heinrich H
Expert Review of Neurotherapeutics, 12, 2012, pp 447-60

Taking back the brain: could neurofeedback training be effective for relieving distressing auditory verbal hallucinations in patients with schizophrenia?
McCarthy-Jones S
Schizophrenia Bulletin, 38, 2012, pp 678-82

A review of neurofeedback treatment for pediatric ADHD.
Lofthouse N, Arnold LE, Hersch S, Hurt E, and DeBeus R
Journal of Attention Disorders, 16, 2012, pp 351-72